Generally very reliable, the main problem is failure of the internal nylon gears. There have been a very few initial failures, I suffered one at 200 miles, but that's rare and warranty covered anyway.
Otherwise, the gear life is directly related to how highly geared the motor is relative to the wheel size, the peak power rating of the system and how much the rider pedal assists, particularly from a standstill.
On the most powerful and high geared setups like the 22 mph assist, 700c wheel eZee Torq 1, failure at about 5000 miles has been fairly common, in hilly areas particularly. On more moderately powered and geared systems, the motor can run trouble free for many thousands of miles with a reasonable amount of rider assistance.
Most suppliers stock gearsets which are not expensive and easy to replace in the screw side cover versions.
Otherwise the only problem that's occurred in my experience has been the odd failed internal Hall sensor, from memory just three reported in this forum in the last five years, so quite rare. In two cases the sensor was replaced since one owner had the necessary skills, the second guided by the first owner in doing the job. However, it's not an easy job and a new motor can be so cheap most consider them not worth repairing this fault.
I've never known a failed bearing and in all other respects they are almost unburstable when used correctly.
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