Rear wheel drive on a car and a bike are rather different.
In general, you want the power going to the wheels with the weight over them for obvious reasons of grip.
On a car, rear wheel drive works OK because it gives handling and grip characteristics which a skilled driver can use to advantage and because on hard acceleration, weight is transferred to the back wheels. On a RWD car weight distribution is more even than a bicycle. A BMW 520 is roughly 51/49 for example.
On a 25kg e-bike with 75kg rider, I don't know what the weight distribution would be but 20kg front 80kg rear wouldn't surprise me. In principle, it would make for very insecure grip characteristics, especially in the wet when turning.
Ideally, you'd add the weight of the motor as low as possible and as near the centre of gravity as possible. That is maybe a plus point of the crank drive systems over hubs. How important it would be I don't know since rear hub drive don't seem to cause any handling problems.